Mineralogical, paragenetic, and geochemical data on sulfidic mineralization from the Cínovec greisen-type deposit show that distribution of sulfides is irregular and not strictly bound to prevalent Li–Sn–W mineralization. Progressive development of metal contents in the reduced sulfide-bearing hydrothermal fluid proceeds from Zn–Cu–Sn to Pb–Bi–Ag and As–Sb. Late-stage sulfate- and fluorine-bearing fluids partly altered earlier mineralization but did not deposit significant ore content.